Scott Fardy makes way for Ryan who is set to see action since injuring his shoulder in the Six Nations clash with England in Twickenham in March.
The other change in the forwards sees Josh van der Flier return at openside flanker, with Will Connors dropping to the bench despite a string of fine performances for the Blues since the resumption.
Ross Byrne is named at out-half in place of Sexton who drops to the bench, with Garry Ringrose taking the captain’s armband.
Jamison Gibson-Park starts a scrum-half in place of Luke McGrath who is named among the replacements.
Leinster: Jordan Larmour, Hugo Keenan, Garry Ringrose, Robbie Henshaw, James Lowe, Ross Byrne, Jamison Gibson-Park, Cian Healy, Ronan Kelleher, Andrew Porter, Devin Toner, James Ryan, Caelan Doris, Josh van der Flier, Jack Conan.
Replacements: James Tracy, Ed Byrne, Michael Bent, Scott Fardy, Will Connors, Luke McGrath, Jonathan Sexton, Rory O’Loughlin.
***See Leinster v Ulster in the PRO14 final tomorrow evening from 6.30pm on eir sport 1.